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Coordinator program • saterland

Zuletzt aktualisiert: vor 26 Tagen
Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

ESQlabs GmbHSaterland, Niedersachsen, DE
Quick Apply
Are you a talented and motivated.Do you enjoy driving innovation and setting new boundaries in.This position offers you this and more exciting work in an innovative and fast-paced environment.Contr...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Digital Transformation Manager (m / f / d)

Digital Transformation Manager (m / f / d)

SennheiserLower Saxony, Germany
Sound made by Sennheiser - For more than 75 years, we are among the world’s leading manufacturers of audio products, building the future of audio. We are proud of our finely engineered microphones a...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
R&D Coordinator OEM (m / w / d)

R&D Coordinator OEM (m / w / d)

Dr. Heimeier Executive SearchNiedersachsen
Unser Mandant ist ein erfolgreicher, global aufgestellter Zulieferer der Automobilindustrie mit mehreren tausend Mitarbeitenden und Werken in Europa, Asien und Nordamerika.Die Gruppe mit Stammsitz ...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
German Speaking Junior Campaign Specialist in Barcelona

German Speaking Junior Campaign Specialist in Barcelona

Cross Border TalentsLower Saxony, Germany
Vollzeit
Quick Apply
Are you a Google fan? Do you love Google products?.Are you passionate about the web and new technology?.If you are tech-savvy, creative, outgoing, and willing to roll up your sleeves and get things...Mehr anzeigenZuletzt aktualisiert: vor 26 Tagen
Test Development Engineer

Test Development Engineer

ic resourcesLower Saxony, Germany
Unbefristet
Are you passionate about pioneering technologies that shape the future? Our client, a global leader in innovative solutions from materials to systems, Our client is at the forefront of empowering m...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Head of Marketing LAB & CCS (m / w / d)

Head of Marketing LAB & CCS (m / w / d)

Straumann GroupNiedersachsen
Equal Opportunity and Affirmative Action Employer (US applicants only).Straumann Group is an equal opportunity employer and will not discriminate against any employee or applicant for employment on...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
HR&GS Coordinator(Stade,Germany)

HR&GS Coordinator(Stade,Germany)

Tecnicas ReunidasBaja Sajonia, Alemania
Coordinate with HR department Home Office Madrid the personnel mobilizations of different departments : date of arrival, welcome. Help and support to our team in Stade with Major registrations and re...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
  • Gesponsert
Graduate Field Applications Engineer - Analog and Mixed-Signal mfd

Graduate Field Applications Engineer - Analog and Mixed-Signal mfd

Renesas ElectronicsGöttingen, Lower Saxony, Germany
We are looking for an enthusiastic and dynamic Field Applications Engineer (FAE) to support our automotive customers in EMEA area focusing on analog and mixed signal products.As a Field Application...Mehr anzeigenZuletzt aktualisiert: vor 26 Tagen
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Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

ESQlabs GmbHSaterland, Niedersachsen, DE
Vor 30+ Tagen
Anstellungsart
  • Quick Apply
Stellenbeschreibung

Are you a talented and motivated life-science modelling & simulation scientist with experience in the pharma industry? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBPK / DDI) modelling ? This position offers you this and more exciting work in an innovative and fast-paced environment.

ESQlabs  is an innovative, internationally acting Contract Research Organization and a global leader in the development and application of the OSP Suite (www.open-systems-pharmacology.org). We are a research-focused provider of specialized computational analyses in the life sciences industry.

To help us grow our global PBPK / DDI impact , we are looking for a Senior / Principal Scientist Systems Pharmacology PBPK / DDI to strengthen our multi-disciplinary project teams for the successful completion of client goals.

Role

  • Complement a dedicated high-performing team of scientists
  • Collaborate with colleagues on multi-disciplinary teams to implement quantitative clinical pharmacology projects / programs and to provide clinical pharmacology and PBPK / DDI consultation to other company projects / programs
  • Provide clinical pharmacology and pharmacometric consulting through advanced PBPK / DDI, and exposure-response modeling and simulation using the OSP-Suite (PK-Sim, MoBi, R), or other tools
  • Support clinical pharmacology-related components of clinical study protocols, study conduct, data analysis, and report writing with the support of colleagues
  • Responsible for appropriateness of methods, integrity of data used for analysis, and accuracy of results
  • Regularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, and messaging of findings
  • Prepare final technical reports, synopses, executive summaries, and other regulatory documents
  • Ensure the provision of advanced literature searches for project / program-related information
  • Provide sophisticated written interpretation of material and integrate research findings into project / program methodology and results
  • Share findings with internal and external project teams; prepare abstracts, presentations, and publication-ready manuscripts
  • Provide mentoring and feedback to junior scientists
  • Integrate knowledge of PBPK and DDI to provide guidance regarding proposed approaches to addressing drug development and regulatory approval challenges
  • Expand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client meetings, and government meetings
  • Develop and teach at OSP-Suite (PK-Sim, MoBi, R), and other workshops and courses

Required skills & experience

  • 5+ years (Principal 10+ years) of applied (pre-)clinical pharmacology experience
  • 3+ years (Principal 5+ years) of leading projects and programs
  • 3+ years (Principal 5+ years) of experience in regulatory applications of PBPK modeling in pre-clinical and clinical development
  • Good knowledge of regulatory requirements and guidelines for PBPK and DDI
  • Strong experience presenting scientific results to professional audiences
  • Extensive experience preparing, submitting, and receiving approval for publications in scientific journals
  • Mechanistic physiologically based pharmacokinetic modeling and simulation experience
  • Expert knowledge in domain-specific modeling software (e.g. PK-Sim® /  MoBi®, SimCyp®, or GastroPlus®)
  • Excellent communication, presentation, and leadership skills
  • Relationship-building skills with the ability to work closely with project leaders and team members
  • Strong organization skills and ability to handle multiple tasks simultaneously
  • Work well handling tight deadlines
  • Great critical-thinking and problem-solving skills
  • Fluency in English (oral and written), German is a plus
  • Education

  • PhD, or masters in quantitative sciences (Bioengineering, Applied Math, ...) with advanced (pre)clinical pharmacology related training or
  • PharmD or PhD in pharmacokinetics, clinical pharmacology, or related field with advanced applied mathematics related training
  • Further qualities that will put you in the spotlight

  • Experience in (IND / NDA) submissions
  • Advanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)
  • Proficiency in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
  • A strong understanding of statistics
  • Therapeutic domain knowledge : Diabetes, Oncology, Immunology or Inflammation
  • Published peer-reviewed articles
  • What's in store for you

    The dynamic team behind ESQlabs unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our open-mindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always willing to broaden our horizons, and love our start-up culture.

    You will also benefit from :

  • Flexible work hours and a home office policy that focuses on people and not on numbers
  • An attractive remuneration package
  • A dedicated budget for education programs and conferences you can attend
  • A working environment in which your contribution will make a difference, and that allows you to take ownership of projects and processes
  • Responsibility, autonomy, participation, and career perspective
  • About us

    We collaborate with global corporations in the pharma and chemical industry, as well as start-ups in the life-science technology sector and academic and non-profit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized treatment of patients and protect the health of the animal and human life.

    ESQlabs has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EU-wide research grants allows us to develop our core technologies continuously.

    For more information about our culture, values and benefits visit our  Unique career opportunities - ESQlabs GmbH .

    At ESQlabs, we are committed to diverse backgrounds and experiences.