DOCTORAL RESEARCHER POSITION (PH.D.) - LIFE SCIENCES, BIOLOGY, (BIO)CHEMISTRY, VETERINARY MEDICINE, MEDICINE, OR PHARMACY

Intro As part of the Research Training Group "Targets in Toxicology - Deciphering therapeutic targets in lung toxicology” (GRK 2338) , we are offering a PhD position focusing on lung biology. The structured Ph.D. program (Ph.D. in Medical Research) combines highly interdisciplinary research projects with specialized training in the pathophysiology of the lung and the entire discipline of toxicology through an internationally renowned research network. The aim of the Research Training Group is to train a new generation of highly qualified toxicologists. Tasks RESEARCH PROJECT : Identification of interaction partners of the pro-inflammatory P2X7 receptor by proximity labeling This research project aims to identify the molecular mechanisms of P2X7 receptor signaling and its involvement in immune cell function and lung diseases. The P2X7 receptor is an ATP-gated ion channel and key mediator of inflammation. Its activation results in a variety of effects (e.g. cytokine secretion, cell morphology changes, apoptosis) that are incompletely understood (Kopp et al. Front. Mol. Neurosci.). In the proposed project we aim to generate, validate and use Turbo-ID-fused P2X7 receptors to identify components of the P2X7 signaling complex that mediate this effect. Personal Investigator : Prof. Dr. phil. nat. Annette Nicke Requirements We are looking for highly motivated researchers with enthusiasm for basic science and a good background in molecular biology and biochemistry Ideal candidates should hold a master’s degree or an equivalent first professional qualification degree in the Life Sciences (e.g. in Biology, (Bio)Chemistry, Veterinary Medicine, Medicine, or Pharmacy) and be proficient in English. The ability to responsibly plan and perform experiments and to work in an international team is expected. Experience in functional analysis of ion channels and transfection / transduction of primary cells is an advantage. Benefits Fixed employment contract (TV-L 13, 65 %) Duration : 3 years Cutting-edge research project at the interface of basic and clinical science international networking and exchange opportunities Excellent scientific environment and state-of-the-art research infrastructure strong group network (13 doctoral students) numerous offers of seminars, workshops and further training measures The institute is located in the middle of Munich and the Bavarian lakes and Alps can be easily reached by public transport in less than 1h. Closing We are looking forward to receiving your application (CV, motivation letter, certificates and two reference letters) until 31.12.2024 . Best wishes, GRK Team