Doctoral (PhD) student position (all genders) in viral immunology

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Doctoral (PhD) student position (all genders) in viral immunology

Main tasks

As part of the newly DFG-funded Collaborative Research Centre (CRC) 1648 Emerging Viruses : Pathogenesis, Structure, Immunity the labs of Julian Schulze zur Wiesch (Infectious Diseases Unit, I.

Department of Medicine, UKE) and Mascha Binder (Medical Oncology and Department of Biomedicine, University and University Hospital Basel) are seeking one highly motivated PhD student to study the cellular and molecular mechanisms that drive protective or damaging adaptive immune responses in emerging viral infections.

Main tasks :

The initial naïve immune responses to novel viral pathogens can be very effective in aiding pathogen clearance, but they might also lead to hyperinflammation or autoimmune-like reactions as observed for SARS-CoV-2 and other infections.

The focus of this research project is to identify cellular and molecular patterns that drive these beneficial or detrimental outcomes and that are shared between different infections.

By using state-of-the-art techniques like multiparameter flow cytometry, ex vivo tetramer staining, immune repertoire sequencing, scRNA / VDJ- and CITE-seq, we will dissect the cellular phenotypes and antigen receptor landscapes of (antigen-specific) B and T cells in well-defined infection and vaccination cohorts for certain viral infections (but not limited to) : .

SARS-CoV-2, Monkeypox (Mpox), or Lassa virus. This includes in-depth examination of immunocompromised and re-infected vaccinated patients to gain insights into recurrent immune dynamics.

A key aspect of this project is to use machine learning tools to transform the obtained data into knowledge that contributes to pandemic preparedness.

Our groups work in inspiring and interactive research environments at the University Medical Center Hamburg-Eppendorf and the Department of Biomedicine in Basel and have ongoing collaborative projects with national and international colleagues.

Primary location will be Hamburg, but regular stays in Basel are possible. Candidates will be expected to take the lead role in the design, conduction and analyses of their projects, contribute to publications, and present their projects and data at lab meetings, as well as international meetings.

We are looking for someone who is excited to discover and answer questions related to viral immunology, and who demonstrates critical thinking, scientific rigor, and attention to detail.

The position is temporary for three years in accordance with the WissZeitVG and to be filled with 65 % of the regular weekly working hours.

Your Profile

• An excellent master’s degree or equivalent in biology, physics, biochemistry, chemistry, molecular life sciences, infection biology or a related subject
• Sound cell and molecular biological skills and knowledge
• Interest in clinical Immunology and virology , Infectious diseases and clinical medicine
• Experience with flow cytometry and / or next-generation sequencing methods are beneficial; Experience with R or python are not required but a plus
• Strong motivation to conduct independent experiments, including planning, analysis and interpretation
• Strong analytical skills and ability to work independently
• Excellent written and oral communication skills in English
• Commitment to teamwork and collaboration
• Some German langue skills are a plus
• Interest in travelling nationally and internationally to work with collaborators of both work groups

Applications should include letter of motivation, a CV including two references, certificates (University entrance, qualification, BSc, and Msc), abstract of MSc thesis (1 page) including a summary of experimental skills and a list of publications (if applicable).

Immunity status

Please note that employment is only possible if there is complete proof of immunization or immunity against the measles virus in accordance with the applicable (legal and medical) requirements.

You must provide proof of this by means of appropriate documents (. vaccination certificate) before commencing employment.

Our Offer

• Regular pay according to TVöD / VKA; attractive company pension plan and various employee discounts
• 30 days of vacation; possibility of special leave
• Central location : Our clinic is centrally located at the beautiful Eppendorfer Park
• Sustainable travel : subsidies for the "Deutschlandticket" and Dr. Bike bicycle service
• Crisis-proof workplace, meaningful activity, appreciative interaction and open exchange of knowledge within the team; structured induction training
• Opportunity to actively shape and develop the working environment within the framework of our employee program (UKE INside).
• Family-friendly working environment : cooperation on childcare, free vacation care, advice for employees with relatives in need of care
• Excellent health, prevention and sports offers
• Healthy and varied lunch break : In addition to our canteen, there is a rich selection of culinary offerings just a few steps away, for example the "Health Kitchen" cafés and bistros, as well as other snack bars, bakers, a supermarket, etc.

Contact

Contact to the department

Prof. Dr. Julian Schulze zur Wiesch

Recruiting contact

Recruiting Team

49 (0) 40 7410-52599

About us

We live diversity and value variety

We offer a work environment providing equal opportunities regardless of age, gender, sexual identity, disability, origin or religion.

This is confirmed by our accession to the Charter of Diversity. We explicitly aim to increase the proportion of women in management positions, especially among scientific personnel in research and teaching.

Women with equal qualifications will be given priority. The same applies in the case of under-representation of one gender in the advertised area.

Persons with severe disability with equal aptitude, competence and professional performance will be given priority.

Learn more about "Diversity at UKE" here.

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