PhD student (m / f / d)

PhD student (m / f / d)

Full-time

Tätigkeitsfeld : Wissenschaft und Forschung

Beschäftigungsumfang : Vollzeit

Company Description

The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) is operated by the Robert Bosch Stiftung. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic and non-genetic factors on variability of drug efficacy and their contributions to disease development.

For a graduate program focusing on “Non-canonical G protein signaling : Mechanism, Functions, Consequences”. The PhD project will address various aspects of cancer therapy and tumor cell biology through -omics data analysis. The project will be closely linked to clinical aspects of cancer research.

Job Description

Bioinformatic analysis of multi-omics data to elucidate the role of nucleoside diphosphate kinases (NDPK) in the tumor microenvironment and their potential influence on cancer progression and metastasis

Characterization of primary tumors and metastasis using multi-omics data sets (e.g. genomics, metabolomics) with focus on single-cell and spatial transcriptomics RNA sequencing data

Integrated analysis of clinical phenotypes and -omics data using biostatistics and bioinformatics

Application of a broad spectrum of established and new bioinformatics analysis strategies with focus on single-cell and spatial transcriptomics RNA seq and data integration

Capacity and enthusiasm to undertake the training activities of a graduate program supported by programs of the Faculty of Medicine and the Graduate Academy of the University of Tuebingen to ensure greatest possible success in your career track

Qualifications

Master degree (M.Sc.) in bioinformatics, applied bioinformatics or a related discipline

Experience and strong background in the analysis of bulk and single-cell RNA sequencing data and data interpretation

Experience in the analysis of multi-omics datasets (e.g. proteomics, transcriptomics, genomics)

Strong programming skills in R, and preferably in Python

Solid background in cancer biology

Good knowledge in biostatistics would be beneficial

Interest in oncology and personalized medicine

Excellent English written and oral communication skills

Additional Information

We offer :

The opportunity to work in an interactive team providing support and mentoring

State-of-the-art equipment and technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities (e.g. core facility “Biostatistics / Bioinformatics, Pharmacometrics and Digital Science”) at the institute

Participation in the PhD program

The opportunity to communicate scientific results at international conferences and to participate in workshops

A unique feature of the educational program is the co-supervision of each PhD student by a team of investigators, which contribute with their unique expertise to the progress of the projects

An initial contract for 3 years and flexible starting date (earliest starting date as of now)

For further information please contact Prof. Dr. Matthias Schwab (phone 0711-8101-3700) or Dr. Elke Schaeffeler (phone 0711-8101-3729).

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