Postdoctoral Researcher (m/f/x) Immune Diversity and Brain Health

One major area of research in our department focuses on the immune system, a critical factor in health and disease, and how it changes with age. We explore how the age-related decline in immune function, known as ‘inflammaging’, is associated with neurodegeneration and other non-communicable diseases. Our ultimate aim is to contribute to the prevention of neurodegenerative and support healthy brain aging.

Our research is primarily based on the Rhineland Study, a prospective cohort study that emphasizes deep phenotyping. To study the role of the immune system in health and disease across the adult livespan, we included FACS analyses, immune stimulation assays and extensive cytokine profiling into our core protocols. We collaborate with partners at Bonn University in the Cluster of Excellence “ImmunoSensation2” and the Collaborative Research Center “Metaflammation”. Additional data include detailed structural and functional brain imaging, cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, and medical history and medication use data. Available multi-omics data, both from baseline and follow-up, include (epi) genomic, transcriptomic, metabolomic, lipidomic, proteomic and microbiome data. The study currently includes over 12,500 individuals, with longitudinal data already available for nearly 5,000 of them. Additional baseline and follow-up data collection is ongoing.

In this context, the group of Prof. Dr. Breteler is looking for an ambitious and experienced researcher (m/f/x) in full time to join the department of Population Health Sciences at the German Center for Neurodegenerative Diseases (DZNE) in Bonn.

You will address questions related to immune diversity and brain health, primarily leveraging the rich data from the Rhineland Study and other large scale cohort studies. In addition to contributing to ongoing projects, you will develop your own research projects and profile. You will contribute to the management of the immunology pipelines, be involved in the supervision of PhD and master’s students, and actively participate in national and international collaborations.

• You hold a PhD in epidemiology, medicine, (bio)medical sciences, bioinformatics, immunology or in a related field
• Knowledge of epidemiological methods, study design, advanced statistics and novel computational methods for data analyses
• Experience in epidemiological research or large-scale observational studies
• Outstanding analytical and communication skills
• Ability to work collaboratively in a dynamic team-oriented environment
• A track record of publishing high quality scientific articles
• Proficiency in spoken and written English is required