Tasks:
You will work in the new Collaborative Research Centre (CRC/SFB 1739) 'Soft tissue–alveolar bone crosstalk - Impact of systemic diseases on mechanisms of periodontal remodelling', which is funded by the German Research Foundation (DFG). You will work on the subproject entitled 'Dissecting the role of the periodontal-immune axis in mechanical induced tissue remodelling using an advanced dynamic 3D in vitro model'.
Your work will focus on developing a multicellular dynamic in vitro tissue model of the periodontal ligament. To achieve this, you will synthesize and characterize customized hydrogel blends based on their rheological and mechanical behavior. You will also assess the biological performance of the different matrices based on the behavior of the cells depending on their composition and the ratio of the embedded cells. These results will be compared with data from animal experiments conducted in other subprojects of the consortium with the aim of refining the in vitro model. You will then study the effects of cyclic loading on the embedded cells in the bioreactor investigating how they impact the remodeling behavior of the artificial tissue. The additional effect of immune cells is of particular interest here, and will be investigated in collaboration with the project partner of our subproject.
Profile:
You have successfully and quickly completed a Master's degree in Biomedical Engineering, Biotechnology or a related field. During your studies, you have acquired specialist knowledge in tissue engineering. You have gained practical experience working in an S1 cell culture laboratory. You are passionate about translational biomedical research and possess excellent communication skills. In addition to your professional qualifications, you demonstrate a high degree of determination and resilience, as well as excellent teamwork skills. You have an excellent command of written and spoken English (Level C1).
Why choose us?
We offer…
Biomedical Engineer or Biotechnologist -PhD candidate- • Aachen, North Rhine-Westphalia
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