DOCTORAL RESEARCHER POSITION PHD - LIFE SCIENCES BIOLOGY BIOCHEMISTRY VETERINARY MEDICINE MEDICINE OR PHARMACY

As part of the Research Training Group Targets in Toxicology Deciphering therapeutic targets in lung toxicology (GRK 2338) we are offering a PhD position focusing on lung biology. The structured Ph.D. program (Ph.D. in Medical Research) combines highly interdisciplinary research projects with specialized training in the pathophysiology of the lung and the entire discipline of toxicology through an internationally renowned research network. The aim of the Research Training Group is to train a new generation of highly qualified toxicologists.

Tasks

RESEARCH PROJECT :

Identification of interaction partners of the proinflammatory P2X7 receptor by proximity labeling

This research project aims to identify the molecular mechanisms of P2X7 receptor signaling and its involvement in immune cell function and lung diseases. The P2X7 receptor is an ATPgated ion channel and key mediator of inflammation. Its activation results in a variety of effects (e.g. cytokine secretion cell morphology changes apoptosis) that are incompletely understood (Kopp et al. Front. Mol. Neurosci.). In the proposed project we aim to generate validate and use TurboIDfused P2X7 receptors to identify components of the P2X7 signaling complex that mediate this effect.

Personal Investigator : Prof. Dr. phil. nat. Annette Nicke

Requirements

• We are looking for highly motivated researchers with enthusiasm for basic science and a good background in molecular biology and biochemistry
• Ideal candidates should hold a masters degree or an equivalent first professional qualification degree in the Life Sciences (e.g. in Biology (Bio)Chemistry Veterinary Medicine Medicine or Pharmacy) and be proficient in English.
• The ability to responsibly plan and perform experiments and to work in an international team is expected.
• Experience in functional analysis of ion channels and transfection / transduction of primary cells is an advantage.

Benefits

The institute is located in the middle of Munich and the Bavarian lakes and Alps can be easily reached by public transport in less than 1h.

We are looking forward to receiving your application until 31.12.2024 .

Best wishes

GRK Team