Principal Scientist Single Cell TCR Analyst (m / f / d)

Scope

We are seeking a highly motivated Principal Scientist specialising in Single-Cell RNA, TCR data analysis, and experience in deep learning, structural biology, and immunology. This role will be a key contributor alongside a team of talented computational biologists and experimental scientists in the Oncology Translational Research Department. The Scientist will be responsible for combining single-cell TCR sequencing analysis with advanced machine learning approaches to predict TCR : peptide-MHC interactions, characterise tumor-reactive T cell repertoires, and develop predictive biomarkers for therapy response in precision immunotherapy programs.

• Lead comprehensive analysis of single-cell RNA-seq with paired TCR sequencing including clonotype identification, repertoire diversity, and integration with transcriptional phenotypes; building and maintaining pipelines in Python.
• Work with deep learning architectures (transformers, graph neural networks, CNNs) for TCR : pMHC interaction prediction using sequence and structural features.
• Collaborate closely with the Oncology Translational Research team members, immunologists, and AI / ML engineers to translate TCR insights into clinical biomarkers.
• Develop predictive biomarker signatures correlating TCR features with clinical outcomes and support companion diagnostic development.

Basic Qualifications & Skills

We are looking for professionals with these required skills to achieve our goals :

Preferred Qualifications & Skills

Please note the following skills are not necessary, just preferred; if you do not have them, please still apply :

Location : Heidelberg, Germany

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Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas : respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.