Postdoctoral Researcher (mfd) in Macromolecular Compartmentalization and Genome Stability

The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the adjacent Center for Systems Biology Dresden (CSBD) are basic research institutes that pursue a mission to advance multiscale biological discovery using interdisciplinary approaches including innovative cutting-edge mathematics physics and computation. Currently about 500 employees from over 50 countries work at the institute in a highly collaborative and curiosity-driven environment. MPI-CBG has twice been awarded the title Best Place to Work (Academia and postdocs) by the journal The Scientist. Employees appreciate the collegial atmosphere as well as the family-friendly and flexible working conditions. The official language of the institute is English.

The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)

is seeking a

Postdoctoral Researcher (m / f / d) in Macromolecular Compartmentalization and Genome Stability

The research group of Nagaraja Chappidi investigates how macromolecular assemblies and compartment-like structures contribute to accurate DNA replication and DNA repair. The research combines purified replication and repair factors with quantitative biochemical and biophysical approachessuch as TIRF microscopy and optical tweezersand integrates these findings with cell-based and where appropriate disease-relevant models. Key questions include how replication and repair factors self-organize into mesoscale structures which emergent biophysical properties arise from this organization and how such compartmentalization improves accuracy efficiency and regulation of genome maintenance. The overarching goal is to define the principles governing coordinated factor assembly selective compartment formation spatial confinement of enzymatic activities and the timely exchange of substrates between molecular players.

Your role :

As a postdoc in the Chappidi group you will drive independent and collaborative research to dissect the mechanistic principles of compartmentalization in DNA replication and DNA repair. Depending on your background and interests you may contribute to :

• reconstituting multi-protein assemblies
• performing quantitative single-molecule or imaging experiments
• developing novel biophysical or biochemical assays
• validating emergent principles in mammalian cells or disease models
• integrating concepts across biophysics biochemistry and genome maintenance

You will also present your findings at internal meetings and international conferences contribute to publications and support a positive and collegial team culture.

Essential qualifications

Strong motivation reliability and ability to work both independently and with a team.

Desirable skills and experience

Our offer :

Your Application :

Please submit your complete application via ouronline system at stating 2025-Postdoc-GenomeCompartmentalization-2560 by 7 January 2026. Kindly include the following :

Scientific inquiries can be sent to Nagaraja Chappidi (). Questions regarding contract compensation or benefits may be addressed to Brian von Rueden ( ).

Max Planck Institute of Molecular Cell Biology and Genetics

Pfotenhauerstr.Dresden Germany

Required Experience :

Unclear Seniority

Key Skills

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Employment Type : Full-Time

Experience : years

Vacancy : 1