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Postdoctoral Researcher – Functional Genomics in AML

Postdoctoral Researcher – Functional Genomics in AML

Universitätsmedizin Frankfurtfrankfurt am main, hessen, Germany
Vor 3 Tagen
Stellenbeschreibung

Knowledge becomes health” – weare filling this motto with life every day, developing new ideasand improving old-established knowledge. The University HospitalFrankfurt has existed since 1914. Our around 8,500 employeescontribute with their skills and knowledge to the 33 specialistclinics, theoretical clinical institutes, and administrativedepartments. The close connection of health care with research andteaching, as well as a climate of collegiality, internationality,and cross-professional cooperation characterize the universityhospital.

Postdoctoral Researcher – FunctionalGenomics in AML

We are targeting applicants ofall genders.)

Full time | Limited to two years |Announcement number : 185-2025

The Department of Hematology and Oncology at theUniversity Hospital Frankfurt provides a comprehensive range ofdiagnostic and therapeutic services for patients with solid tumorsand malignancies of the hematopoietic system. Within thisscientific environment, the research group, led by Prof. Dr. med.Thomas Oellerich, focuses on uncovering oncogenic signalingpathways, regulators of tumor viability, and mechanisms ofresistance to therapies, with a primary emphasis on acute myeloidleukemia (AML) and aggressive lymphomas.

Fordetails visit https : / / lymphoma-leukemia-research-frankfurt.de orrefer to key publications,including :

  • Phelan, Scheich et al.,Cancer Cell (2024)
  • Jayavelu, Wolf, Buettner etal., Cancer Cell (2022)
  • Mohr et al., CancerCell (2017)
  • Schneider, Oellerich et al.,Nature Medicine (2017)
  • Phelan et al., Nature(2018)

The Oellerich Lab leveragescutting-edge proteogenomics and functional genomics to explore themolecular underpinnings of hematological cancers. The laboratory ispart of the Frankfurt Cancer Institute (FCI) and the GermanConsortium for Translational Cancer Research (DKTK), supported bythe research infrastructure of the University Hospital Frankfurtand the Georg-Speyer-Haus. Strategic collaborations withinternational institutions, including the NIH and the Dana-FarberCancer Center, further enhance the lab’s globalimpact.

The lab is seeking a motivatedpostdoctoral researcher to join a project funded by the GermanCancer Aid (Deutsche Krebshilfe). The role focuses on elucidatingmolecular mechanisms of oncogenesis and therapy resistance in AML.The candidate will develop multiplexed, high-throughput functionalgenomic screens to dissect the roles of oncogenic drivers andresistance pathways.

The lab employs a wide arrayof experimental techniques,including :

  • Single-cell CRISPR / Cas9screening technologies
  • Quantitative(phospho-)proteomics
  • Next-generation sequencing(NGS) and single-cell RNAsequencing
  • Fluorescence-activated cell sorting(FACS) and advanced flowcytometry
  • High-resolution imaging technologies,such as proximity ligation assays (PLAs) and super-resolutionmicroscopy
  • Computationalbiology

    • For an insight into theUniversity Hospital Frankfurt, click here.

    Yourrole

  • Independently establishingmultiplex, high-throughput genomic screens inAML
  • Independently designing and carrying outfollow-up scientific projects, planning, establishing, andanalyzing in vitro as well as in vivoexperiments
  • Handling primary patient material,for example bone marrow MNCs, performing FACS analysis andquantification
  • Writing manuscripts andgrants
  • Presenting scientific data at nationaland international conferences
  • Training andinstructing scientific employees (technical assistants, MD and PhDdoctoral candidates) allocated to theproject

    • Who youare

  • The applicant should hold a PhDdegree in biology, biochemistry, molecular medicine, or a relatedlife science, ideally in cancerresearch.
  • Theoretical and practical expertisein molecular biology (e.g., cloning, PCR) and protein biochemicaltechniques – experimental as well as in cell culture (e.g.production of virus particles for genomic modifications)techniques
  • Experience with the principles andapplication of functional genomic tools, such as CRISPR / Cas9-basedtechnologies
  • Expertise with high-throughputgenomic assays (e.g., bulk and / or single cell RNA-sequencing) is anadvantage.
  • Experienced handling of analyticalsoftware (e.g. Office, FlowJo, Illustrator) is required, additional(bio)informatics skills (e.g., processing and analysis ofsequencing data using software, R or Python) or a strong interestto acquire these skills is encouraged.
  • Trackrecords of publications in peer-reviewed journals areexpected.
  • A high level of motivation andinterest in answering scientific questions in an interdisciplinaryacademic cancer research setting
  • Flexibilityand responsibility, as well as very good communication skills inGerman or English
  • Motivation to learn, apply,and establish new techniques, ability to critically analyze andreflect data
  • Due to legal regulations, validproof of measles immunity / measles vaccination isrequired.

    • What weoffer

  • We offer you an interesting,versatile, and attractive working environment ina highly motivated, international team consisting of MDs and PhDs with background in basic science, cancerbiology, and translational leukemia / lymphoma research in a labwith modern state-of-the-art infrastructure ;access to comprehensive further training program with access toDKTK School of Oncology and Mildred-ScheelNetwork.
  • Collectiveagreement : In addition to an attractive salary based on acollective agreement with an annual special payment, you benefitfrom long-term security through company pensionschemes.
  • Mobility : Freepublic transport in all Hesse (Free HesseStateTicket)
  • Campus : Ourattractive university hospital campus offers a modern cafeteria,various cafes, and opportunities to rest in numerous green spaces.A walk on the riverside of the Main offers relaxation duringbreaks.
  • Work-Life-Balance : Part-time employment is possible. We offer childcare in our daycarecenter (if you have any questions, please contactUKF-Familienservice) and child care duringholidays.
  • Health Promotion : Benefit from our attractive health offers. We offer regular onlineand face-to-face courses on nutrition, relaxation, sports, andexercise.
  • Professionaldevelopment : Internal and external training for yourprofessional development
  • Anyquestions? Many answers can be found in our FAQs for newemployees. If you have any further questions, please do nothesitate to contact us.

    • Women areunderrepresented in these positions at the University HospitalFrankfurt. Applications from women are therefore particularlywelcome. Disabled applicants are preferred if they have the samepersonal and professional qualifications.

    Joinour team

    Use the time until March 4, 2025, toapply. Please submit your online application including a possiblestarting date and your salary expectations. For further informationregarding the position and project, please contact Dr. med.Sebastian Wolf (e-mail : [email protected]).

    UniversitätsmedizinFrankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurtam Main | Please submit your application exclusively via the "Applynow” button. You are welcome to send any queries [email protected]. Please note that no documents will be returned.| Follow us on Instagram (@unimedizin_ffm), XING, andLinkedIn.