StellenbeschreibungInvestigate epigenetic mechanisms underlying AML by dissecting how altered chromatin states disrupt differentiation and maintain leukemia in a collaborative team of biologists and medical scientistsFocus on chromatin biology and its interplay with transcriptional dysregulation in cancerWork with cell line systems, hiPSC-based disease models, primary patient samples, and PDX modelsPlan and perform experiments within the framework of the scientific project plan, including epigenetic assays, gene expression analysis, cloning, lentiviral transductions, and genome editingPrepare and present project reports and contribute to publicationsMD or PhD in biology, biochemistry, molecular biology, or equivalentStrong expertise in molecular biology techniques including Western blotting, immunoprecipitations, epigenetic assays, cloning, cell culture, lentiviral transductions, and gene expression analysisExperience with at least two of the following : flow cytometry, microscopy, NGS techniques and analysis, CRISPR-based epigenetic or genome editingInterest and ideally hands-on experience in bioinformatics analysis of NGS data (ChIP-seq, CUT&Tag, RNA-seq, ATAC-seq)Demonstrated ability in writing scientific reports and papersProficiency with MS Office, graphic programs (Illustrator, ImageJ), statistical software (GraphPad Prism), and bioinformatics tools (R, BLAST)Fluent in both written and spoken EnglishGoal-oriented, individual training and development opportunities including conferences and workshopsWorking with the latest techniques / technical equipment in a state-of-the-art research environmentFlexible working hours within the framework of flexitimePossibility of habilitationCollectively agreed remuneration according to TV-L E13, attractive company pension scheme (VBL)30 days vacationSustainable travel : job ticketFamily-friendly working environment : cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of careWide range of health, prevention and sports offers