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PhD Student on the topic “Delineation of metastatic drivers in gastric cancer”

PhD Student on the topic “Delineation of metastatic drivers in gastric cancer”

DKFZDresden, DE
Vor 23 Tagen
Stellenbeschreibung

PhD Student on the topic “Delineation of metastatic drivers in gastric cancer”

Reference number : 2024-0379

Dresden

Full-time

DKTK partner site Dresden - Junior Research Group "Forward Genetics for Translational Solid Cancer Research"

Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

Together with university partners at seven renowned partner sites, the German Cancer Research Center (DKFZ) has established the German Cancer Consortium (DKTK).

For the Junior Research Group " Forward Genetics for Translational Solid Cancer Research " at the DKTK partner site Dresden , we are seeking for the next possible date a

In the Junior Research Group "Forward Genetics for Translational Solid Cancer Research", we study different cancer phenotypes, from resistance to therapy to metastatic competence. Physiologically relevant modeling systems are utilized, including mouse models and 3D organoid cultures. The unifying methodological framework are forward genetic screens that aim to delineate genetic determinants of a given phenotype. Our screens make use of a range of Cas9 modalities to mimic different patterns of gene expression. The ultimate goals are the identification of drivers of therapy resistance and metastasis and, consequently, the development of new therapeutics to target these processes.

Your Tasks

  • Perform an in vivo CRISPR screen to identify metastasis drivers in gastric cancer
  • Functional investigation of hits through omics approaches
  • Validation of genes mediating metastasis in an in vivo model
  • Work in cooperation with clinicians, computational biologists, and genetic engineering experts

Your Profile

  • Master's degree in biology, biotechnology, biomedicine or related fields
  • Previous experience in working with mice
  • Familiarity with cancer biology, especially cancer genomics
  • Expertise in mammalian cell culture; familiarity with 3D culture is a bonus
  • Basic skills in molecular biology techniques such as cloning, nucleic acid isolation, PCR, Western blot
  • Familiarity with basic CRISPR techniques
  • Strong commitment and motivation to work independently
  • Desire to perform in an international and dynamic team
  • Fluency in spoken and written English

    • We Offer

    Excellent framework conditions : state-of-the-art equipment and opportunities for international networking at the highest level

    Access to international research networks

    Doctoral salary with the usual social benefits

    30 days of vacation per year

    Flexible working hours

    Possibility of part-time work

    Family-friendly working environment

    Sustainable travel to work : subsidized Germany job ticket

    Unleash your full potential : targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service

    Our Corporate Health Management Program offers a holistic approach to your well-being

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