Biologe (f / m / x)

Founded in 1607, Justus Liebig University Giessen (JLU) is a research university rich in tradition. Inspired by curiosity about the unknown, we enable around 26.500 students and 5,700 employees to advance science for society. Join us in breaking new ground and writing success stories - your own and those of our university.

Support us as of now in part-time (65 %) as a

PhD student (m / f / d) / Research Associate (m / f / d) - Functional Genomic Analysis of B-Cell Lymphomas

The position is to be filled on a fixed-term basis in accordance with § 2 WissZeitVG and § 72 HessHG with the opportunity for own academic qualification for the duration of three years at the Professorship for Cytology with focal point of lymphoproliferative Diseases, Department of Pathology at the Faculty of Medicine. The salary is in accordance with the collective labor agreement of the State of Hessen (E 13 TV-H / 65%).

As long as the maximum permissible duration of a fixed-term contract is not exceeded, you will be employed for a period of 3 years. An extension for up to another 2 years is possible under the above-mentioned condition.

Project background

While large-scale cancer genome sequencing has revealed the mutational landscape of many B-cell lymphomas, identifying the specific oncogenic drivers and understanding their functional roles remains a significant challenge. Recent advancements in functional genomics now allow us to bridge the gap between genomic discovery and biological insight. By combining large-scale genomic sequencing with functional screening approaches, we can identify and characterize the functional consequences of genetic alterations in B-cell lymphomas.

Our previous research has identified several mutations in putative tumor suppressor genes in germinal center B-cell-derived lymphomas. Importantly, we observed significant differences in the prevalence and mutational patterns of these genes across various lymphoma subtypes. To further elucidate the functional roles of these candidate tumor suppressor genes, we are employing CRISPR / Cas9-based genome-wide screening in relevant cell line models. Our goal is to comprehensively investigate the contribution of these genetic alterations to the pathogenesis of B-cell lymphomas.

Your tasks at a glance

• Explore the molecular phenotype of primary ex-vivo cultured human GC B cells induced by candidate tumor suppressor gene inactivation
• Characterize the functional significance of gene inactivation in B cell lymphoma cell lines
• Investigate signaling pathways that act synergistically to tumor suppressor gene mutations
• Opportunity for own academic and didactic qualification, activities in research and teaching according to § 72 HessHG
• Taking on teaching duties according to the teaching obligation ordinance of the state of Hessen

Your qualifications and competences

Our offer to you