Clinical research associate Jobs in Bannewitz

Research for a life without cancer“ is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

The National Center for Tumor Diseases (NCT) is a long-term cooperation between the German Cancer Research Center (DKFZ), excellent partners in university medicine and other research institutions at six locations in Germany. The goal of the NCT is to bring promising results from cancer research into clinical application quickly and safely. This approach is intended to provide cancer patients with nationwide access to innovative treatment options.

One of the six NCT sites is the NCT Dresden (NCT / UCC), which is a collaboration between the DKFZ, the University Hospital Carl Gustav Carus Dresden (UCC), the Carl Gustav Carus Medical Faculty of the TU Dresden and the Helmholtz Center Dresden-Rossendorf (HZDR).

The Department for Translational Medical Oncology is looking for as soon as possible a (Senior) Bioinformatician.

Reference number : 2025-0109

NCT and DKFZ have laid the groundwork to address new challenges in personalized oncology through the MASTER program. This prospective registry trial employs very comprehensive molecular profiling and integrated data analysis (WGS / WES, RNA sequencing, genome-wide DNA methylation profiling; whenever possible mass spectrometry-based (phosphor)proteomics, ex vivo drug sensitivity profiling and spatial resolution of the immune environment). Based on the MASTER workflow we provide clinically relevant management recommendations in a multicenter molecular tumor board (MTB) and follow-up on clinical management of patients. The resulting multidimensional clinical and molecular dataset has kick-started very successful interdisciplinary research projects (e.g. Heining et al. Cancer Discov 2018, Gröschel et al. Nat Commun 2019, Horak et al. Cancer Discov 2021, Möhrmann et al. Nat Commun 2022, Jahn et al. Ann Oncol 2022).

The Department for Translational Medical Oncology investigates the molecular and cellular mechanisms for cancer development, proliferation and evolution. The department engages in clinical as well as experimental activities to ensure a rapid turnaround of scientific results into clinical application and clinical outcome into new hypotheses. Experimentally, high-throughput, multi-parametric molecular profiling is used to discover differences in the genome of tumor and normal cells to identify novel targets for cancer therapy on the genomic or cellular level. Suitable model systems are developed and used to functionally and mechanistically characterize the impact of novel targets and assess their potential for clinical application.

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