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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de

Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN .Hybrid, 2-3 days on-s... Mehr anzeigen

Data Center Technician Germany Onsite

RM Staffing B.V.Ludwigshafen am Rhein, RP, DE

Ludwigshafen am Rhein, Germany.This is an on-site position supporting mission-critical infrastructure at premier data center facilities.Rates vary based on experience level and project complexity.E... Mehr anzeigen

Laboratory Scientist - Automation (Proteomics) (m/f/d) - Inklusiver Job 🦼 🦻 🦯

GSKHeidelberg, Baden-Württemberg, DE

Laboratory Scientist – Automation (Proteomics) (m/f/d) .At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better, and live longer.We are a science-led ... Mehr anzeigen

Werkstudent (w/m/d) Data Management

Siemens AGMannheim, Baden-Wuerttemberg, DE

Mannheim - Baden-Wuerttemberg - Germany.Befristet / Teilzeit; (15-20 Stunden / Woche).Starte als Werkstudent Data Management (w/m/d) in Mannheim und gestalte mit uns die Zukunft des Vertriebs durch... Mehr anzeigen

SAP iXp Intern (f/m/d) - People Insights Data Scientist

SAPWalldorf, DE

At SAP, we keep it simple: you bring your best to us, and we'll bring out the best in you.We're builders touching over 20 industries and 80% of global commerce, and we need your unique talents to h... Mehr anzeigen

Regulatory Scientist - Metabolism-Study Monitor (m/f/d)

BASF DeutschlandLudwigshafen am Rhein, de

Regulatory Scientist - Metabolism-Study Monitor (m/f/d).We are BASF in agriculture and everything we do, we do for the love of farming.Our solutions are purpose-designed for different crop systems,... Mehr anzeigen

Deine Chance: Datenmanagement Upskilling - SQL, Microsoft Azure & Power BI für den schnellen

Smart Future Campus GmbHMannheim, Baden-Württemberg, Deutschland

Der Smart Future Campus ist ein wichtiger Anbieter von Weiterbildung und Qualifizierung im Bereich der IT, Industrie 4.KI, Unity und digitaler Transformation.Mit praxisnahen Kursen, anerkannten Zer... Mehr anzeigen

 • Gesponsert

Scientist Produktentwicklung (gn) (65000 € - 75000 € per year)

Trenkwalder DeutschlandMannheim, DE
Quick Apply

Scientist Produktentwicklung (m/w/d).Unser Kunde, die Roche Diagnostics GmbH, ist mit rund 15.Mitarbeitern (m/w/d) an mehreren Standorten in Deutschland vertreten.Als führendes Unternehmen im Berei... Mehr anzeigen

Laboratory Scientist - Automation (Proteomics) (m/f/d)

GSKHeidelberg

At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better, and live longer.We are a science-led global healthcare company focusing on discovering and de... Mehr anzeigen

Senior Data Scientist ML & Engineering (m/w/d)

PAUL Tech AGMannheim, Baden-Württemberg, Germany
Quick Apply

Technologieführer der Immobilienwirtschaft mit der.Unsere Lösung PAUL Net Zero kombiniert KI, IoT-Geräte und Wärmepumpen zu einem.Sanierungsaufwand oder Investitionsrisiko.Du brennst für robuste Ma... Mehr anzeigen

Corporate Real Estate Manager (m/f/d)

BASF Agricultural Solutions Deutschland GmbHLimburgerhof, Germany

We are BASF in Agriculture and everything we do, we do for the love of farming, and the biggest job on Earth.We are an internationally successful company of the BASF Group.Our solutions are purpose... Mehr anzeigen

 • Gesponsert

Senior Experte Sensorik / Senior Sensory Scientist (m/w/d)

ADM WILD Europe GmbH & Co. KGEppelheim, Baden-Württemberg, Germany

Bevor Sie sich für diese Stelle bewerben, lesen Sie bitte die folgenden Informationen über diese Gelegenheit.Senior Sensory Scientist (m/w/d) im Bereich CD&D (Consumer Design & Development) Getränk... Mehr anzeigen

 • Gesponsert

Senior Data Integration Lead (m/f/d)

DEU Medtronic GmbHGermany,Württemberg,Baden,Mannheim

At Medtronic you can begin a life-long career of exploration and innovation, while helping champion healthcare access and equity for all.You’ll lead with purpose, breaking down barriers to innovati... Mehr anzeigen

Praktikum Data Science

Lidl Stiftung & Co KGHockenheim, DE

Werde Teil unseres Daten & KI Teams, unterstütze datenbasierte Analysen und entwickle innovative Automatisierungslösungen.Erhalte Einblicke in Big Data und Machine Learning Technologien.Mitarbe... Mehr anzeigen

Senior Director Translational Data Sciences

GSKHeidelberg

We are a science-led, global pharmaceutical company committed to closing the gap between biological discovery and clinical impact.Our translational mission is to decode the molecular and cellular a... Mehr anzeigen

Mathematiker / Data Scientist (m/w/d) Statistik & Datenanalyse für PoC-Systeme in Mannheim (915)

BRÜGGEN ENGINEERING GmbHMannheim, Baden-Württemberg, Germany
Quick Apply

Ihre Karriere in der pharmazeutischen Datenanalyse – mitgestalten, wo Mathematik auf Medizintechnik trifft.Mit BRÜGGEN ENGINEERING datengetriebene Diagnostiklösungen gestalten: In dieser Position w... Mehr anzeigen

Mapping Data Collection Driver

Terry SootHeidelberg

Safely operate client-provided vehicles equipped with mapping and data collection equipment.Collect mapping data within assigned zones efficiently and in compliance with project guidelines.Handle a... Mehr anzeigen

Post-doctoral scientist (m/w/d)

Universitätsklinikum HeidelbergHeidelberg, Deutschland

Molecular and cell biology techniques.Wet lab techniques of geneomic and transciptomic analyses.Dry lab bioinformatic analyses of genomic and transcriptomic data sets .Enthusiastic about discovery ... Mehr anzeigen

Scientist (m/w/d) – Biologics Drug Product Development / Early Manufacturing Process Development

actcon GmbHLudwigshafen, de

Scientist (m/w/d) – Biologics Drug Product Development / Early Manufacturing Process Development JETZT BEWERBEN .L... Mehr anzeigen

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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de
Vor 30+ Tagen
Stellenbeschreibung
(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN

Contract work: Temporary employment

Duration: approx. 2 years (initially 18 months)

Location: Hybrid, 2-3 days on-site Mannheim/FFM and 2-3 days remote

Start: End of March/beginning of April

Salary: approx. €150,000 to €180,000 gross per year

Pharmacometrics is concerned with the mathematical and statistical analyses and modeling of biological, pharmacological, and physiological data and processes. It quantifies the various aspects of the (desired and undesired) effects of drugs in the context of disease. The models are based on clinical data, and provide a basis for informing efficient drug development, regulatory decisions, and optimal treatment of patients.

Purpose:

We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.

This means:

  • Develop QSP platform models for multiple oncology mechanisms including:
    • Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
    • Antibody-drug conjugates across lung, ovarian, and colorectal cancers
    • T-cell engagers and bispecifics/trispecifics in multiple myeloma
    • CAR-T therapies in hematologic malignancies
  • Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
  • Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
  • Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
  • Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group

Your Profile:

  • PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development
  • Proven scientific track record and practical experience in several of the following areas
    • Statistical modeling
      • Modeling with differential equations
      • Scripting languages (R, Matlab, Python)
      • Drug development
  • Critical thinking and self-reflective
  • Persistent and resilient
  • Ability to connect unrelated concept and to generate original or unique ideas
  • very deep knowledge in the operational construction of the models
  • Experience with QSP models
  • Fluency in English required, German would be a plus
  • very good communication skills

Die Job@ctive GmbH steht für Kompetenz und Leidenschaft in den unterschiedlichsten Bereichen des Personalmanagements, ganz gleich ob Personalberatung, -beschaffung oder -vermittlung. Wir stellen unseren renommierten Kunden bei Personalengpässen und saisonbedingten Arbeitsspitzen unsere Mitarbeiter zur Verfügung.

STELLENDETAILS

EINSATZORT 67061 Ludwigshafen
Rheinland-Pfalz
Deutschland

BRANCHE Chemie & Pharma

REFERENZNUMMER 29578504
KONTAKTDATEN
Jobactive GmbH
Herr Dong Chen
Campusallee 2
51379 Leverkusen
+49 221 67026756
+49 176 15400598
dong.chen@jobactive
.actcon-gmbh JETZT BEWERBEN MIT: BEWERBUNGSFORMULAR E-MAIL