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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de

Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN .Hybrid, 2-3 days on-site Mannheim/FFM and 2-3 days remote.End of March/beginning of April.Pharmacometric...Mehr anzeigen

Traineeprogram START IN Finance & Controlling with focus Controlling (m/f/d)

BASF DeutschlandLudwigshafen am Rhein, de

Traineeprogram START IN Finance & Controlling with focus Controlling (m/f/d).We are BASF in agriculture and everything we do, we do for the love of farming.Connecting seeds and traits, crop protect...Mehr anzeigen

FABRIC SOURCING & DEVELOPMENT MANAGER (M/W/D)

DOROTHEE SCHUMACHERMannheim, Germany

Ready to become part of the DOROTHEE SCHUMACHER Family?.Leave your creative footprint and help us transform the now into a better tomorrow.To strengthen our team, we are looking for a full-time can...Mehr anzeigen

Customer Success Manager - German speaker (m/f/d)

NielsenIQMannheim, Baden-Württemberg, Germany

NielsenIQ Customer Success places our customers at the heart of everything that we do.We strive to offer a consistent customer experience across all our markets by harmonizing our ways of working, ...Mehr anzeigen

Junior Recruiter (m/w/d)

DISMannheim, Baden-Württemberg, DE

Du hast ein Gespür für Menschen, Kommunikation liegt dir im Blut und du willst im Recruiting durchstarten?.Hier wird Recruiting nicht als Pflicht gesehen, sondern als Chance, echte Verbindungen zu ...Mehr anzeigen

Sales Account Executive (m/f/x)

MyJoVE CorporationLudwigshafen am Rhein, Germany

JoVE is the world-leading producer and provider of science video solutions with the mission to improve scientific research and education.Millions of scientists, educators and students use JoVE for ...Mehr anzeigen

 • Gesponsert • Neu!

Talent Acquisition Specialist (m/w/d)

PAUL Tech AGMannheim, Baden-Württemberg, Germany
Quick Apply

Technologieführer der Immobilienwirtschaft mit der.Unsere Lösung PAUL Net Zero kombiniert KI, IoT-Geräte und Wärmepumpen zu einem.Sanierungsaufwand oder Investitionsrisiko.Du bist im Recruiting zuh...Mehr anzeigen

Scientist Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

HaysGR. Mannheim

Scientist Advanced MIDD & Quantitative Systems Pharmacology.Mannheim Startdatum: sofort Referenznummer: 865214/1.Diesen Job teilen oder drucken.Entwicklung von QSP-Modellen für IO/ICI, ADCs, T-Zell...Mehr anzeigen

Doctoral Position in Political Communication (3+1 years)

University of ZurichAndreasstrasse 15, 8050 Zürich, Switzerland

Acquiring detailed knowledge of the literature on political communication, political engagement, social media communication, and information flows, as well as on new methodologies (e.A thematic foc...Mehr anzeigen

Senior Manager M&A Projects & Integration (m/f/d) Corporate Strategic Initiatives

PHOENIX Pharma SEMannheim

Senior Manager M&A Projects & Integration (m/f/d) Corporate Strategic Initiatives.Join PHOENIX! Support us in supplying the people of Europe with medicines and healthcare products quickly and relia...Mehr anzeigen

Junior Recruiter (m/w/d)

DIS AGMannheim, Baden-Württemberg, Deutschland

Du hast ein Gespür für Menschen, Kommunikation liegt dir im Blut und du willst im Recruiting durchstarten?.Hier wird Recruiting nicht als Pflicht gesehen, sondern als Chance, echte Verbindungen zu ...Mehr anzeigen

PhD student (f/m/d) Institute of Clinical Chemistry

Medizinische Fakultät MannheimMannheim, Baden-Württemberg, Germany

Are medicine and research in your blood? Then we're looking for you! The University Medical Center Mannheim stands for quality-assured, university-based maximum care and is one of the largest medic...Mehr anzeigen

 • Gesponsert

SAP ABAP Manager

Pertemps ERPMannheim, Baden-Württemberg, Germany
Quick Apply

This is a hands-on leadership role, where you will split your time between managing a talented SAP development team and contributing directly to ABAP projects.The role is Hybrid, (2-3 days per week...Mehr anzeigen

Senior Software Verification Engineer (m/f/d)

6918 Roche Diabetes Care GmbHMannheim, DE

At Roche you can show up as yourself, embraced for the unique qualities you bring.Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted ...Mehr anzeigen

 • Neu!

System Engineer Primärtechnik stationäre Batteriespeicher (m/w/d)

BKWMannheim

Technische Verantwortung im System Engineering der Primärtechnik für Batteriespeicher – von der Projektentwicklung bis zur Inbetriebnahme und Betriebsunterstützung.Erstellung technischer Unterlagen...Mehr anzeigen

(Senior) Scientist Electromagnetic Actuation Technologies (m/f/d)

ABBMannheim, Baden-Wurttemberg, Germany

You’ll be empowered to lead, supported to grow, and proud of the impact we create together.Join us and help run what runs the world.Research Team Manager - Mechanisms & Actuators.The work model for...Mehr anzeigen

HR Assistant / Recruiting (m/w/d) mit Türkischkenntnissen -Teilzeit oder Minijob

IT ElektrorecyclingMannheim, Baden-Württemberg, Germany
Quick Apply

Wir suchen ab sofort Unterstützung im Bereich.Wenn du gerne mit Menschen arbeitest,.Job gut zu dir passen – auch wenn dein Deutsch nicht perfekt ist.Kleinanzeigen, Facebook, Online-Portale).Beantwo...Mehr anzeigen

Digital Transformation Manager (m/f/d)

PHOENIX International Holdings GmbHMannheim

Digital Transformation Manager (m/f/d).Join PHOENIX! Support us in supplying the people of Europe with medicines and healthcare products quickly and reliably - and experience a job that is as diver...Mehr anzeigen

Auszubildende Kauffrau/Kaufmann im Groß- und Außenhandelsmanagement (m/w/d)

Antech DiagnosticsViernheim, Germany

We understand that the world we want tomorrow starts with how we do business today, and that’s why we’re inspired to make A Better World for Pets.Antech is comprised of a diverse team of individual...Mehr anzeigen

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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de
Vor 30+ Tagen
Stellenbeschreibung
(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN

Contract work: Temporary employment

Duration: approx. 2 years (initially 18 months)

Location: Hybrid, 2-3 days on-site Mannheim/FFM and 2-3 days remote

Start: End of March/beginning of April

Salary: approx. €150,000 to €180,000 gross per year

Pharmacometrics is concerned with the mathematical and statistical analyses and modeling of biological, pharmacological, and physiological data and processes. It quantifies the various aspects of the (desired and undesired) effects of drugs in the context of disease. The models are based on clinical data, and provide a basis for informing efficient drug development, regulatory decisions, and optimal treatment of patients.

Purpose:

We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.

This means:

  • Develop QSP platform models for multiple oncology mechanisms including:
    • Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
    • Antibody-drug conjugates across lung, ovarian, and colorectal cancers
    • T-cell engagers and bispecifics/trispecifics in multiple myeloma
    • CAR-T therapies in hematologic malignancies
  • Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
  • Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
  • Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
  • Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group

Your Profile:

  • PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development
  • Proven scientific track record and practical experience in several of the following areas
    • Statistical modeling
      • Modeling with differential equations
      • Scripting languages (R, Matlab, Python)
      • Drug development
  • Critical thinking and self-reflective
  • Persistent and resilient
  • Ability to connect unrelated concept and to generate original or unique ideas
  • very deep knowledge in the operational construction of the models
  • Experience with QSP models
  • Fluency in English required, German would be a plus
  • very good communication skills

Die Job@ctive GmbH steht für Kompetenz und Leidenschaft in den unterschiedlichsten Bereichen des Personalmanagements, ganz gleich ob Personalberatung, -beschaffung oder -vermittlung. Wir stellen unseren renommierten Kunden bei Personalengpässen und saisonbedingten Arbeitsspitzen unsere Mitarbeiter zur Verfügung.

STELLENDETAILS

EINSATZORT 67061 Ludwigshafen
Rheinland-Pfalz
Deutschland

BRANCHE Chemie & Pharma

REFERENZNUMMER 29578504
KONTAKTDATEN
Jobactive GmbH
Herr Dong Chen
Campusallee 2
51379 Leverkusen
+49 221 67026756
+49 176 15400598
dong.chen@jobactive
.actcon-gmbh JETZT BEWERBEN MIT: BEWERBUNGSFORMULAR E-MAIL