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Zuletzt aktualisiert: vor 5 Tagen
Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

ESQlabs GmbHSaterland, Niedersachsen, DE
Quick Apply
Are you a talented and motivated.Do you enjoy driving innovation and setting new boundaries in.This position offers you this and more exciting work in an innovative and fast-paced environment.Contr...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
  • Gesponsert
Inspector electrical auxiliary and LV systems (w / m / d)

Inspector electrical auxiliary and LV systems (w / m / d)

Brunel GmbHBorkum, Deutschland
Exciting Offshore Opportunities!.German North Sea! If you have a strong technical background and experience in electrical, HV / MV, or telecom systems, this could be the perfect opportunity for you.C...Mehr anzeigenZuletzt aktualisiert: vor 5 Tagen
Marketing Communications Specialist (m / w / d)

Marketing Communications Specialist (m / w / d)

people-s-place GmbHGermany, Lower Saxony
Planning, developing, coordinating, and managing B2B marketing and communication measures for one specific company division. Expanding and further developing existing marketing and communication act...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Territory Manager

Territory Manager

Bose ProfessionalNiedersachsen - Westfalen, Remote, DE
Homeoffice
Quick Apply
Company Overview : Bose Professional is backed by a dedicated group of engineers, project managers, technical support professionals, and sales staff. They all support professional audio system integr...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Baubegleiter TGA HLSK (m / w / d)

Baubegleiter TGA HLSK (m / w / d)

STF Gruppe GmbHNiedersachsen, Deutschland
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Baubegleiter TGA HLSK (m / w / d) bei STF Gruppe GmbH | softgarden.Seit über 25 Jahren bieten wir maßgeschneiderte und innovative Lösungen in den Bereichen Telekommunikation, IT, Digitalisierung und TG...Mehr anzeigenZuletzt aktualisiert: vor 11 Tagen
Digital Transformation Manager (m / f / d)

Digital Transformation Manager (m / f / d)

SennheiserLower Saxony, Germany
Sound made by Sennheiser - For more than 75 years, we are among the world’s leading manufacturers of audio products, building the future of audio. We are proud of our finely engineered microphones a...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Senior Expert Project Mangement & Analytics (all genders)

Senior Expert Project Mangement & Analytics (all genders)

EurofinsFriesoythe, NDS, DE
For one of our teams based in Friesoythe, we are currently looking for a Senior Expert Project Mangement & Analytics (all genders) . In this exciting and interesting role, your responsibilities woul...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
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Ingenieur •in (m / w / d) im Projektmanagement Bereich Energietechnik

Ingenieur •in (m / w / d) im Projektmanagement Bereich Energietechnik

THOST Projektmanagement GmbHverschiedene Standorte, Niedersachsen, DE
Ingenieur •in (m / w / d) im Projektmanagement Bereich EnergietechnikTeilzeit / VollzeitBremen, Hamburg, Leipzig, Göttingen, Lübeck, Dresden, WürzburgJob ID VE2504Ihre AufgabenProjektsteuerung, Organisa...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
(Senior) Manager, Medical Science Liaison, Therapy Development, Transcatheter Mitral and Tricuspid Therapies (Germany)

(Senior) Manager, Medical Science Liaison, Therapy Development, Transcatheter Mitral and Tricuspid Therapies (Germany)

Edwards LifesciencesGermany, Niedersachsen, Remote
Homeoffice
Vollzeit
Innovation starts from the heart.At Edwards, we put patients first.We invest a significant proportion of our revenue towards research and development to drive and develop groundbreaking medical inn...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
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Graduate Field Applications Engineer - Analog and Mixed-Signal mfd

Graduate Field Applications Engineer - Analog and Mixed-Signal mfd

Renesas ElectronicsGöttingen, Lower Saxony, Germany
We are looking for an enthusiastic and dynamic Field Applications Engineer (FAE) to support our automotive customers in EMEA area focusing on analog and mixed signal products.As a Field Application...Mehr anzeigenZuletzt aktualisiert: vor 14 Tagen
HR&GS Coordinator(Stade,Germany)

HR&GS Coordinator(Stade,Germany)

Tecnicas ReunidasBaja Sajonia, Alemania
Coordinate with HR department Home Office Madrid the personnel mobilizations of different departments : date of arrival, welcome. Help and support to our team in Stade with Major registrations and re...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Senior Project Manager - System on Chip

Senior Project Manager - System on Chip

ic resourcesLower Saxony, Germany
Unbefristet
Our client, a Global Leader in optical, and Laser technology, is seeking a dynamic individual to take responsibility for their projects in SoC development. With the opportunity to be based in Berlin...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
Project Manager Real Estate (m / w / d)

Project Manager Real Estate (m / w / d)

HaysNiedersachsen
Project Manager Real Estate (m / w / d).Festanstellung durch unseren Kunden Niedersachsen Startdatum : sofort Referenznummer : 766155 / 1. Diesen Job teilen oder drucken.Als modernes Unternehmen entwickelt ...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
German Speaking Google Ads Sales Account Manager in Barcelona

German Speaking Google Ads Sales Account Manager in Barcelona

Cross Border TalentsLower Saxony, Germany
Vollzeit
Quick Apply
Join our dynamic team at Teleperformance in vibrant Barcelona and work on an exciting project with Digital Marketing Ads — a game-changing tool for businesses everywhere!.If you are tech-savvy, cre...Mehr anzeigenZuletzt aktualisiert: vor 23 Tagen
Projektleiter im Bereich Engineering (m / w / d)

Projektleiter im Bereich Engineering (m / w / d)

Lieken Brot- und Backwaren GmbHGarrel, Niedersachsen, Deutschland
Quick Apply
Projektleiter im Bereich Engineering (m / w / d).Mit uns sind Sie ganz nah am Brot – und an Karrieremöglichkeiten und Aufgaben in den verschiedensten Bereichen in der Brot- und Backwarenwelt...Mehr anzeigenZuletzt aktualisiert: vor über 30 Tagen
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Job in Germany : Systemadministrator / in Firewall und Webgateway (w / m / d)

Job in Germany : Systemadministrator / in Firewall und Webgateway (w / m / d)

Zentraler IT Betrieb Niedersächsische JustizNiedersachsen
ZIB is the central IT service provider for the justice system in Lower Saxony and is responsible for a modern IT infrastructure with around 23,500 clients. Together with our 400 colleagues, we also ...Mehr anzeigenZuletzt aktualisiert: vor 10 Tagen
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Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

Senior / Principal Scientist Systems Pharmacology PBPK / DDI (m / f / d)

ESQlabs GmbHSaterland, Niedersachsen, DE
Vor 30+ Tagen
Anstellungsart
  • Quick Apply
Stellenbeschreibung

Are you a talented and motivated life-science modelling & simulation scientist with experience in the pharma industry? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBPK / DDI) modelling ? This position offers you this and more exciting work in an innovative and fast-paced environment.

ESQlabs  is an innovative, internationally acting Contract Research Organization and a global leader in the development and application of the OSP Suite (www.open-systems-pharmacology.org). We are a research-focused provider of specialized computational analyses in the life sciences industry.

To help us grow our global PBPK / DDI impact , we are looking for a Senior / Principal Scientist Systems Pharmacology PBPK / DDI to strengthen our multi-disciplinary project teams for the successful completion of client goals.

Role

  • Complement a dedicated high-performing team of scientists
  • Collaborate with colleagues on multi-disciplinary teams to implement quantitative clinical pharmacology projects / programs and to provide clinical pharmacology and PBPK / DDI consultation to other company projects / programs
  • Provide clinical pharmacology and pharmacometric consulting through advanced PBPK / DDI, and exposure-response modeling and simulation using the OSP-Suite (PK-Sim, MoBi, R), or other tools
  • Support clinical pharmacology-related components of clinical study protocols, study conduct, data analysis, and report writing with the support of colleagues
  • Responsible for appropriateness of methods, integrity of data used for analysis, and accuracy of results
  • Regularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, and messaging of findings
  • Prepare final technical reports, synopses, executive summaries, and other regulatory documents
  • Ensure the provision of advanced literature searches for project / program-related information
  • Provide sophisticated written interpretation of material and integrate research findings into project / program methodology and results
  • Share findings with internal and external project teams; prepare abstracts, presentations, and publication-ready manuscripts
  • Provide mentoring and feedback to junior scientists
  • Integrate knowledge of PBPK and DDI to provide guidance regarding proposed approaches to addressing drug development and regulatory approval challenges
  • Expand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client meetings, and government meetings
  • Develop and teach at OSP-Suite (PK-Sim, MoBi, R), and other workshops and courses

Required skills & experience

  • 5+ years (Principal 10+ years) of applied (pre-)clinical pharmacology experience
  • 3+ years (Principal 5+ years) of leading projects and programs
  • 3+ years (Principal 5+ years) of experience in regulatory applications of PBPK modeling in pre-clinical and clinical development
  • Good knowledge of regulatory requirements and guidelines for PBPK and DDI
  • Strong experience presenting scientific results to professional audiences
  • Extensive experience preparing, submitting, and receiving approval for publications in scientific journals
  • Mechanistic physiologically based pharmacokinetic modeling and simulation experience
  • Expert knowledge in domain-specific modeling software (e.g. PK-Sim® /  MoBi®, SimCyp®, or GastroPlus®)
  • Excellent communication, presentation, and leadership skills
  • Relationship-building skills with the ability to work closely with project leaders and team members
  • Strong organization skills and ability to handle multiple tasks simultaneously
  • Work well handling tight deadlines
  • Great critical-thinking and problem-solving skills
  • Fluency in English (oral and written), German is a plus
  • Education

  • PhD, or masters in quantitative sciences (Bioengineering, Applied Math, ...) with advanced (pre)clinical pharmacology related training or
  • PharmD or PhD in pharmacokinetics, clinical pharmacology, or related field with advanced applied mathematics related training
  • Further qualities that will put you in the spotlight

  • Experience in (IND / NDA) submissions
  • Advanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)
  • Proficiency in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
  • A strong understanding of statistics
  • Therapeutic domain knowledge : Diabetes, Oncology, Immunology or Inflammation
  • Published peer-reviewed articles
  • What's in store for you

    The dynamic team behind ESQlabs unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our open-mindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always willing to broaden our horizons, and love our start-up culture.

    You will also benefit from :

  • Flexible work hours and a home office policy that focuses on people and not on numbers
  • An attractive remuneration package
  • A dedicated budget for education programs and conferences you can attend
  • A working environment in which your contribution will make a difference, and that allows you to take ownership of projects and processes
  • Responsibility, autonomy, participation, and career perspective
  • About us

    We collaborate with global corporations in the pharma and chemical industry, as well as start-ups in the life-science technology sector and academic and non-profit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized treatment of patients and protect the health of the animal and human life.

    ESQlabs has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EU-wide research grants allows us to develop our core technologies continuously.

    For more information about our culture, values and benefits visit our  Unique career opportunities - ESQlabs GmbH .

    At ESQlabs, we are committed to diverse backgrounds and experiences.