Postdoctoral Fellow in Structural Biology and Evolution of Chromatin
Your role
The successful candidate will work on a cutting-edge experimental research project in the structure-function analysis of chromatin in archaea.
The goal of the project is to understand how eukaryotes evolved histone tails and tail-based regulatory mechanisms from an archaeal ancestor, and what role could the tails play in proto-eukaryotic chromatin.
Practically, we will merge tail-less histones of a model archaeon with selected eukaryotic or Asgard histone tails in vitro and in vivo and investigate the structural and functional effects on a molecular level.
The project involves a combination of biochemistry, biophysics, and structural biology work. Structural part of the project will involve cryo-EM single particle analysis of nucleosomes, as well as FIB-milling of archaeal cells, and cryo electron tomography (cryo-ET) and subtomogram averaging of chromatin fibres.
Moreover, this project is a close collaboration with the laboratory of Naomichi Takemata (Kyoto University), and will involve regular communication and scientific exchange with the collaborators.
Closing date : 31 July 2024
Contract duration : 3 years
Grading : Year 1 stipend - €4,010 per month after tax
Reference number : HD02627
Related
You have
- PhD in structural biology, molecular biology, biochemistry, or related disciplines (or you are close to finishing your PhD).
- Experience in cryo-EM / cryo-ET data acquisition and processing.
- Experience in biochemistry (protein expression & purification, DNA-protein complex characterization).
- Confidence in working via command line.
- Strong interest in the research topic, high motivation and commitment.
- Ability to work independently and creatively, in an international team with a highly collaborative atmosphere.
- Excellent communication and presentation skills, fluency in English.
You might also have
- Experience in microbiology and handling of anaerobic microorganisms.
- Basic programming skills.
- Familiarity with HPC computing.
Postdoctoral Fellow in Structural Biology and Evolution of Chromatin
Structural part of the project will involve cryo-EM single particle analysis of nucleosomes, as well as FIB-milling of archaeal cells, and cryo electron tomography (cryo-ET) and subtomogram averaging of chromatin fibres. Practically, we will merge tail-less histones of a model archaeon with selected...
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