Postdoctoral Researcher in Cancer-Microbiome Interactions and Translation Control

Postdoctoral Researcher in Cancer-Microbiome Interactions and Translation Control

Reference number : 2025-0311

Heidelberg, Mannheim

Full-time

Translational Gastrointestinal Oncology and Preclinical Models

The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members.

The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network.

Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health.

The Junior Clinical Cooperation Unit " Translational Gastrointestinal Oncology and Preclincial Models " at the German Cancer Reserch Center is seeking for the next possible date a

The Junior Clinical Cooperation Unit (headed by Prof. Dr. med. Johannes Betge) aims to identify cancer vulnerabilities and uncover mechanisms of treatment resistance by using patient-derived cancer models and high-throughput methods, such as drug screening, -omics, and single-cell technologies. Together with the group of Dr. Johanna Schott (Department of Biochemistry, Mannheim Medical Faculty), focused on RNA biology and mechanisms of translation control, we offer a postdoctoral position within the framework of the newly funded Research Unit „Functional Genomics and Microbiomics in Precision Medicine of Colorectal Cancer“ (GenoMiCC, FOR 5806).

Your Tasks

• Gain important insights into clinically relevant aspects of colorectal cancer biology and influences of microbiota
• Apply a wide spectrum of genetic, molecular, cell biological, biochemical as well as -omics and bioinformatics techniques
• Optimize and apply ribosome profiling and single-cell ribosome profiling on organoids and clinical samples
• Characterize the impact of gut microbiota-derived metabolites on signaling pathways, translation control, and therapy resistance in patient-derived colorectal cancer organoids and clinical samples
• Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists, and other colleagues within our research groups and with consortium partners of the FOR 5806

Your Profile

We are looking for a self-motivated, bright individual with a master's and PhD degree in biochemistry, biology, bioinformatics, molecular medicine, or a related subject. Previous experience with biochemical and molecular biology techniques, as well as a strong interest in molecular cancer research are essential. Prior experience with RNA biology, organoid models, high-throughput methods, or -omics analysis is an advantage, but not mandatory. Due to the interdisciplinary framework and close collaboration between two labs and within the FOR 5806, excellent communication skills in English, the ability to work independently, and strong organizational skills are expected.

We Offer

Excellent framework conditions : state-of-the-art equipment and opportunities for international networking at the highest level

Remuneration according to TV-L incl. occupational pension plan and capital-forming payments

30 days of vacation per year

Flexible working hours

Possibility of part-time work

Family-friendly working environment

Sustainable travel to work : subsidized Germany job ticket

Our Corporate Health Management Program offers a holistic approach to your well-being

Develop your full potential : access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents