PhD Student – HIV Pathogenesis and Human Lymphoid Models (m/f/d)
Universitätsklinikum Heidelberg • Heidelberg, Deutschland
Vor 3 Stunden
Stellenbeschreibung
- You will develop and optimize human lymphoid organ culture models, including tonsil explants and aggregate cultures, to investigate adaptive immune responses and HIV-1 pathogenesis
- Using tissue engineering and microfluidic approaches, you will establish next-generation ex vivo lymphoid models with improved longevity, immune competence, and suitability for long-term HIV infection studies
- Your work will focus on enabling the investigation of viral persistence and the establishment of HIV latency in human tissue-based model systems
- You will apply these models to study the mechanisms of action of the HIV pathogenesis factor Nef and its impact on host immune functions
- In collaboration with interdisciplinary research teams, you will examine the anti-HIV activity of neutrophils and their role in antiviral immune responses
- Furthermore, you will evaluate de novo immune responses to novel vaccine candidates developed within the Excellence Cluster SynthImmune
- You will analyze and present scientific data, contribute to publications in international journals, and actively participate in collaborative research activities within the project network
- Master's degree in Immunology, Biology, Biochemistry, Molecular Life Sciences, or a related field
- Solid background in immunology and a strong interest in infection biology and translational research
- Experience with primary human immune cell culture and/or organoid or tissue-based model systems is an advantage
- Practical expertise in flow cytometry is desirable
- Excellent English communication skills, both written and spoken
- Genuine scientific curiosity and enthusiasm for interdisciplinary research
- A collaborative, proactive, and well-organized working style rounds off your profile
- Collectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers