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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de

Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN .Hybrid, 2-3 days on-s... Mehr anzeigen

Senior Expert Lean & Learning (m/f/d)

PHOENIX Pharma SEMannheim

Senior Expert Lean & Learning (m/f/d).Join PHOENIX! Support us in supplying the people of Europe with medicines and healthcare products quickly and reliably - and experience a job that is as divers... Mehr anzeigen

Data Analyst / Business Inelligenece Manager (m/w/d)

bedropMannheim, Baden-Württemberg, Germany
Quick Apply

Während unsere Großeltern noch regelmäßig natürliche Produkte wie Honig und Propolis in die Ernährung der Familie zur Unterstützung des Immunsystems integrierten, findet man heute so gut wie keine ... Mehr anzeigen

 • Neu!

Junior Consultant Digital Supply Chain (m/w/d)

aioneersMannheim, DE

Mission: Unternehmen in die Lage zu versetzen, bessere, schnellere und KI-gestützte Entscheidungen in ihrer Supply Chain zu treffen.Mit unserem Beratungsansatz und innovativen Analytics- und Busine... Mehr anzeigen

Regulatory Scientist - Metabolism-Study Monitor (m/f/d)

BASF DeutschlandLudwigshafen am Rhein, de

Regulatory Scientist - Metabolism-Study Monitor (m/f/d).We are BASF in agriculture and everything we do, we do for the love of farming.Our solutions are purpose-designed for different crop systems,... Mehr anzeigen

Scientist Produktentwicklung (gn) (65000 € - 75000 € per year)

Trenkwalder DeutschlandMannheim, DE
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Scientist Produktentwicklung (m/w/d).Unser Kunde, die Roche Diagnostics GmbH, ist mit rund 15.Mitarbeitern (m/w/d) an mehreren Standorten in Deutschland vertreten.Als führendes Unternehmen im Berei... Mehr anzeigen

Scientist I/II – Container Closure Systems (Parenteral Products) (m/f/d)

GULP – experts unitedLudwigshafen am Rhein

As a Scientist in Container Closure Systems, you will drive the development of primary packaging for high-impact pipeline assets including monoclonal antibodies.You will leverage your expertise to ... Mehr anzeigen

Corporate Real Estate Manager (m/f/d)

BASF Agricultural Solutions Deutschland GmbHLimburgerhof, Germany

We are BASF in Agriculture and everything we do, we do for the love of farming, and the biggest job on Earth.We are an internationally successful company of the BASF Group.Our solutions are purpose... Mehr anzeigen

 • Gesponsert

Senior Data Scientist ML & Engineering (m/w/d)

PAUL Tech AGMannheim, Baden-Württemberg, Germany
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Technologieführer der Immobilienwirtschaft mit der.Unsere Lösung PAUL Net Zero kombiniert KI, IoT-Geräte und Wärmepumpen zu einem.Sanierungsaufwand oder Investitionsrisiko.Du brennst für robuste Ma... Mehr anzeigen

Praktikum Electrical Service Engineering (m/w/d)

CaterpillarMannheim, Baden-Wurttemberg, Germany

Your Work Shapes the World at Caterpillar Inc.When you join Caterpillar, you're joining a global team who cares not just about the work we do – but also about each other.We are the makers, problem ... Mehr anzeigen

Power System Analysis and Solution Algorithms Engineer

Hitachi RailOffice_Mannheim Further Strasse
Homeoffice

We are looking for a passionate and proficient industrial specialist with expertise in power system analysis/ management and high-level programming.In an inter-disciplinary environment, you will dr... Mehr anzeigen

Power Grids Cybersecurity Researcher (f/m/d)

HITACHI ENERGY GERMANY AGGermany,Wurttemberg,Baden,Mannheim

We are looking for a research scientist with expertise in Cybersecurity to join our Research Center in Mannheim (Germany).You will join a dynamic, motivated and creative team with a broad range of ... Mehr anzeigen

Python Software Engineer - Machine Learning Systems (m/f/d)

CUJUFrankenthal, Rhineland-Palatinate, Germany
Homeoffice
Quick Apply

Location: Hybrid/ Remote (Germany-based).Start: ASAP | Languages: Fluent English.Note that we cannot provide any visa or relocation support.Make the Unseen seen! Our goal is to reinvent scouting in... Mehr anzeigen

KI Prompt Engineer/AI Consultant (m/w/d) – 100% remote

mycareernow GmbHFrankenthal (Pfalz), DE
Homeoffice

AZAV zertifizierter Bildungsträger mit klarem Fokus auf Projektmanagement und Künstliche Intelligenz.Unsere praxisnahen Weiterbildungen bereiten dich gezielt auf den nächsten Karriereschritt vor – ... Mehr anzeigen

Senior AI / Data Science Engineer mit Erfahrung im Bereich LLM (m/w/d)

auteega GmbhMannheim / Remote, DE
Homeoffice

Als Tochterunternehmen eines der größten unabhängigen Softwarehäuser Deutschlands ist unser Kunde auf fachspezifische Software für Privatanwender spezialisiert.Im Fachsegment ist unser Kunde mit de... Mehr anzeigen

Sales Manager (m/w/d) - für unsere Fachzeitschrift "personal manager"

HRM Institute GmbH & Co. KGMannheim, Baden-Württemberg, Germany

Das HRM Institute konzipiert, organisiert und realisiert Live- und Digital-Formate im In- und Ausland: Fachmessen, Expofestivals und Online-Konferenzen zu den Themen Personalmanagement, Recruiting,... Mehr anzeigen

 • Gesponsert

Scientist (m/w/d) Verschlusssysteme / Qualitätssicherung Pharma in Ludwigshafen am Rhein (1688)

BRÜGGEN ENGINEERING GmbHLudwigshafen, Rhineland-Palatinate, Germany
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Ihre Karriere in der Qualitätssicherung pharmazeutischer Systeme.Mit BRÜGGEN ENGINEERING arbeiten Sie an der Entwicklung und Bewertung von Verschlusssystemen für parenterale Arzneimittel.Sie beglei... Mehr anzeigen

Scientist (m/w/d) – Biologics Drug Product Development / Early Manufacturing Process Development

actcon GmbHLudwigshafen, de

Scientist (m/w/d) – Biologics Drug Product Development / Early Manufacturing Process Development JETZT BEWERBEN .L... Mehr anzeigen

Laboratory Manager – Device and Combination Development (all genders)

AbbVie Deutschland GmbH & Co. KGLudwigshafen am Rhein

Laboratory Manager – Device and Combination Development (all genders) * Ludwigshafen, RP * Research & Development * Full-time * As of now * permanent * Job ID: R JETZT BEWERBEN About AbbV... Mehr anzeigen

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(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d)

Jobactive GmbHLudwigshafen, de
Vor 30+ Tagen
Stellenbeschreibung
(Senior) Scientist, Advanced MIDD & Quantitative Systems Pharmacology (m/w/d) JETZT BEWERBEN

Contract work: Temporary employment

Duration: approx. 2 years (initially 18 months)

Location: Hybrid, 2-3 days on-site Mannheim/FFM and 2-3 days remote

Start: End of March/beginning of April

Salary: approx. €150,000 to €180,000 gross per year

Pharmacometrics is concerned with the mathematical and statistical analyses and modeling of biological, pharmacological, and physiological data and processes. It quantifies the various aspects of the (desired and undesired) effects of drugs in the context of disease. The models are based on clinical data, and provide a basis for informing efficient drug development, regulatory decisions, and optimal treatment of patients.

Purpose:

We are building comprehensive Model-Informed Drug Development (MIDD) capabilities in-house to create reusable platform models across our oncology portfolio. We seek a talented and motivated expert to develop advanced Quantitative Systems Pharmacology (QSP) models in oncology that enable Virtual Population simulations. You will act as a MIDD expert for oncology and integrate this knowledge into Clinical Pharmacology strategy for related development programs.

This means:

  • Develop QSP platform models for multiple oncology mechanisms including:
    • Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
    • Antibody-drug conjugates across lung, ovarian, and colorectal cancers
    • T-cell engagers and bispecifics/trispecifics in multiple myeloma
    • CAR-T therapies in hematologic malignancies
  • Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
  • Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
  • Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs
  • Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group

Your Profile:

  • PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development
  • Proven scientific track record and practical experience in several of the following areas
    • Statistical modeling
      • Modeling with differential equations
      • Scripting languages (R, Matlab, Python)
      • Drug development
  • Critical thinking and self-reflective
  • Persistent and resilient
  • Ability to connect unrelated concept and to generate original or unique ideas
  • very deep knowledge in the operational construction of the models
  • Experience with QSP models
  • Fluency in English required, German would be a plus
  • very good communication skills

Die Job@ctive GmbH steht für Kompetenz und Leidenschaft in den unterschiedlichsten Bereichen des Personalmanagements, ganz gleich ob Personalberatung, -beschaffung oder -vermittlung. Wir stellen unseren renommierten Kunden bei Personalengpässen und saisonbedingten Arbeitsspitzen unsere Mitarbeiter zur Verfügung.

STELLENDETAILS

EINSATZORT 67061 Ludwigshafen
Rheinland-Pfalz
Deutschland

BRANCHE Chemie & Pharma

REFERENZNUMMER 29578504
KONTAKTDATEN
Jobactive GmbH
Herr Dong Chen
Campusallee 2
51379 Leverkusen
+49 221 67026756
+49 176 15400598
dong.chen@jobactive
.actcon-gmbh JETZT BEWERBEN MIT: BEWERBUNGSFORMULAR E-MAIL