PhD Student in Quantitative Spatial Cancer biology research group

Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge.

The University Hospital Frankfurt has existed since 1914. Our around 7,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments.

The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital.

PhD Student in Quantitative Spatial Cancer biology research group(We are targeting applicants of all genders)Full time limited up to 4 years Announcement number : 497-2024We are seeking a motivated PhD Student to join our Quantitative Spatial Cancer Biology" research group at the Dr.

Senckenberg Institute of Pathology MSNZ Frankfurt , an excellence program supporting careers in Translational Cancer Research (funded by the German Cancer Aid).

The lab, headed by Dr. Konstantinos Kokkaliaris, specializes in hematopoietic stem-cell biology and bone marrow tissue organization in health and cancer.

We use innovate single-cell protein profiling technologies including cutting-edge multiplexed tissue imaging, multicolor flow cytometry and mass cytometry.

The focus of the lab is to better understand tissue organization in homeostasis, cancer and aging and further develop multiplex tissue imaging modalities.

Publications : Kokkaliaris KD , et al, Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations.

Blood. 2020; 136(20) : 2296-2307. *co-corresponig author, Cover storyCoutu DL'. Kokkaliaris KD*. Kunz L* and Schroeder T.

Multicolor quantitative confocal imaging cytometry. Nature Methods 2018; 15 : 39-46 *co-first authorsCoutu DL*. Kokkaliaris KD*.

Kunz L and Schroeder T Three-dimensional map of non-hematopoietic bone marrow cells and molecules. Nature Biotechnology 2017, 35(12) 1202-1210.

co-first authors, Cover StoryYour role Clonal hematopoiesis (CH) is a common age-related condition characterized by the outgrowth of mutated hematopoietic clones which can lead to life-threatening malignancies.

CH is caused by mutations in hematopoietic stem cells (HSCs) and is accelerated in individuals with ischemic hearth failure.

This DFG funded project aims to define the key bone marrow components and cell-extrinsic signais involved in promoting CH following hearth failure.

Using established animals models, patient cohorts and cutting-edge single-cell quantitative biology, we will uncover the underlying mechanism of targeted candidate signals from bonw marrow niches.

Our goal is to leverage those findings towarsds the design of novel therapeutic strategies to decelerate outgrowth of mutated hematopoietic clones.

Who you are Master's degree in Life Sciences or equivalentBasic experience in laboratory techniques (i.e. molecular biology)Background in immunofluorescence microscopy and hematopoiesis are a plusPassion for discovery, collaborative spirit & good communication skillsGood knowledge of spoken and written EnglishDue to legal regulation, a valid proof of measles immunity / measles vaccination is required.

What we offerCollective agreement : In addition to an attractive salary based on a collective agreement (65% E13) with an annual special payment, you benefit from long-term security through company pension schemesMobility : Free public transport in all Hessen (Free State Ticket Hessen)Campus : Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces.

A walk on the riverside of the Main offers relaxation during breaksWork-Life-Balance : Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact Ms.

Häfner at 069 / 6301 83863), child care during holidaysHealth Promotion : Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and excercies.

Professional development : Internal and external training for your professional developmentWomen are underrepresented in these positions at the University Hospital Frankfurt.

Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.

Join our teamUse the time until July 12, 2024 to apply. Please submit your online application including a a possible starting time and your salary expectations.

For further information on the position, please contact Dr. Konstantinos Kokkaliaris, E-Mail : [email protected].

de . Apply nowUniversitätsklinikum Frankfurt Recruiting Team Theodor-Stern-Kai 7 60590 Frankfurt am Main Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button Online bewerben ein.

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