Post - Doctoral Researcher

Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge.

The University Hospital Frankfurt has existed since 4. Our around 8, employees contribute with their skills and knowledge to the specialist clinics, theoretical clinical institutes, and administrative departments.

The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital.

Post - Doctoral Researcher

We are targeting applicants of all genders)

Full time limited Announcement number : -4

The position is to be filled at the Department of Hematology / Oncology of the University Hospital Frankfurt at the earliest possible date.

The Department of Hematology / Oncology of the University Hospital Frankfurt offers a broad diagnostic and therapeutic spectrum for patients with solid tumors, as well as malignant diseases of the hematopoietic system.

The post-doctoral research position is funded by the German Cancer Aid (Deutsche Krebshilfe) to elucidate proteogenomic mechanism of oncogenesis and therapy resistance in acute myeloid leukemia (AML).

The project will focus on the functional characterization of oncogenic mechanisms in acute leukemia by application of proteogenomic approaches in order to identify new therapeutic vulnerabilities that can be targeted by innovative drugs.

To answer our scientific questions we are applying the following experimental techniques (among others) : Innovative CRISPR-Cas9 screening technologies, quantitative (phospho-)proteomic analyses, NGS, FACS analysis and cell sorting, innovative imaging technologies (e.

g. PLAs and high resolution microscopy), mouse experiments.

Your role

• Independently design scientific projects, plan, establish, and analyze in vitro as well as in vivo experiments
• Write manuscripts and grants
• Presentation of scientific data at national and international conferences
• Train and instruct scientific employees (technical assistants, MD and PhD doctoral candidates) allocated to the project

Who you are

• The applicant should hold a PhD degree in biology, molecular medicine or a related life science, ideally in cancer research.
• Fundamental theoretical and practical expertise in molecular biology (e.g. cloning, PCR) and protein biochemical techniques-experimental as well as in cell culture (e.

g. production of virus particles for genomic modifications) techniques.

• Track record of publications in peer-reviewed journals are expected.
• A high level of motivation and interest in answering scientific questions in an interdisciplinary academic cancer research setting.
• Flexibility and responsibility, as well as very good communications skills in German or English
• Experience with high-throughput-screening analyses (e.g. RNAseq., NGS) and in vivo mouse experiments (FELASA B or C certificate) is an advantage.
• Motivation to learn, apply and establish new techniques, ability to critically analyze and refect data.
• Very good computational skills (PowerPoint, Excel, Word, GraphPad Prism, FlowJo, Adobe Illustrator, data analysis with R or python is an advantage).
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required.

What we offer

Work environment : We offer you an interesting, versatile, and attractive working environment in a highly motivated, international team consisting of MDs and PhDs with background in basic science, cancer biology and translational leukemia / lymphoma research in a lab with modern state-of-the-art infrastructure;

access to comprehensive further training program with access to DKTK School of Oncology and Mildred-Scheel Network.

• Collective agreement : In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
• Mobility : Free public transport in all Hessen (Free State Ticket Hessen)
• Campus : Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces.

A walk on the riverside of the Main offers relaxation during breaks

• Health Promotion : Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.
• Professional development : Internal and external training for your professional development
• Any questions? Many answers can be found in our for new employees. If you have any further questions, please do not hesitate to contact us.

Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome.

Disabled applicants are preferred if they have the same personal and professional qualifications.

Join our team